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This easy meatloaf recipe is for cheese lovers only! There’s an entire 8 ounce brick of ooey gooey melted cheddar cheese in the middle of this Jalapeno Cheddar Stuffed Meatloaf that takes it over the top!

Jalapeno Cheddar Stuffed Meatloaf cut in half with the cheddar cheese oozing out.

People have raved over my Mozzarella Stuffed Meatloaf for years. I figured it was time to bring you a new one. And I have to say, this may be my favorite meatloaf yet! This easy meatloaf recipe may quickly become a family favorite?

Can’t handle the heat?

That’s okay! You can easily leave the jalapeno out of this meatloaf recipe to keep the heat out of the kitchen. Jalapeno adds extra flavor and heat, but this meatloaf is still delicious without it.

Plain bread crumbs or Italian style bread crumbs?

This recipe calls for plain bread crumbs and the addition of Italian seasoning. If you have Italian bread crumbs, feel free to use those in place of both!

Jalapeno Cheddar Stuffed Meatloaf topped with Jalapenos sitting on a white platter.

What kind of ground beef should I use to make meatloaf?

When it comes to meatloaf, you don’t want to use ground beef that has too high of a fat content or your meatloaf will be greasy. Use too low of a fat content and your meatloaf may dry out. The best meatloaf is made with an 85/15 fat ratio. You can find the fat ratio listed on your package of ground beef.

If you like this recipe, you may be interested in some of my other meatloaf recipes:

Watch the video below where I walk you through every step of this recipe. Sometimes it helps to have a visual, especially when it comes to stuffing the meatloaf. I’ve got you covered with a step by step cooking show tutorial. If you want to see my full collection of video recipes you can browse them on YouTube or right here on my website with their recipes.

stuffed meatloaf recipe

Jalapeno Cheddar Stuffed Meatloaf cut in half with the cheddar cheese oozing out.
This easy meatloaf recipe is for cheese lovers only! There's an entire 8 ounce brick of ooey gooey melted cheddar cheese in the middle of this Jalapeno Cheddar Stuffed Meatloaf that takes it over the top!
Prep Time 10 minutes
Cook Time 1 hour
Total Time 1 hour 10 minutes
Ingredients
  • 2 pounds ground beef 85/15
  • 1 cup plain bread crumbs
  • 1 tablespoon Italian seasoning
  • 1 teaspoon salt
  • 1/2 teaspoon black pepper
  • 1/2 cup milk
  • 1 large egg
  • 2 tablespoons worcestershire sauce
  • 1 to 2 jalapenos minced
  • 8 oz brick cheddar cheese

GLAZE:

  • 1 cup ketchup
  • 1/4 cup brown sugar tightly packed
  • 1 tablespoon worcestershire sauce
  • 1 tablespoon red wine vinegar
  • 2 cloves garlic crushed
  • 1/8 teaspoon salt
  • pinch cayenne pepper
  • 1 jalapeno sliced
Instructions
  • Preheat oven to 350 degrees. Lightly grease a 9x13 pan with nonstick cooking spray.
  • In a large mixing bowl combine ground beef, bread crumbs, Italian seasoning, salt, pepper, milk, egg, worcestershire sauce, and minced jalapeno. Knead until combined.
  • Divide meat in half. Shape one half of the meat into the bottom half of the loaf and place in prepared pan. Place cheddar cheese brick in the center. Shape remaining half of meat as the top half of the loaf, sealing the edges. This is a free-form loaf so it doesn't need to be perfect.
  • In a small mixing bowl whisk together ketchup, brown sugar, worcestershire sauce, red wine vinegar, garlic, salt, and cayenne pepper. Pour over shaped loaf to coat. Lay sliced jalapenos out on top of the meatloaf to garnish.
  • Bake in the preheated oven for 60 to 80 minutes until cheese is completely melted and meat reaches an internal temperature of a minimum of 160 degrees F.
Notes

Nutrition

Calories: 721kcal | Carbohydrates: 36g | Protein: 40g | Fat: 45g | Saturated Fat: 20g | Cholesterol: 176mg | Sodium: 1372mg | Potassium: 734mg | Fiber: 1g | Sugar: 20g | Vitamin A: 695IU | Vitamin C: 5.9mg | Calcium: 398mg | Iron: 5.2mg

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Bri

5 stars
I used ground turkey and it was amazing! I added extra sharp cheddar cheese on top to garnish. This is the best meatloaf. I’m so glad I found this recipe!

Christina Williams

5 stars
I made 2 one the original way and I tried with pepper jack with the 2nd it was awesome?. Thanks so much.

Rosie

Do you cover it when putting in oven?

Kathy

Can you mix up on the two pounds of meat, using some ground turkey or chicken with the beef.

Dawn

Can I use white vinegar instead of red wine vinegar?

Jeff

Thank you for the recipe! I made this and it was devoured by my meat and cheese loving family!!!

Yupp… I’m gonna need that ASAP. Delicious!!!

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