Cheesy Chicken Spaghetti is a family comfort food favorite! This recipe uses a from-scratch sauce that is super easy to make so that your delicious cheesy casserole is ready for the oven in just 15 minutes.

a red and white baking dish filled with cheesy chicken spaghetti

We can’t get enough of this cheesy twist on a classic recipe. Is anyone else over spaghetti with tomato sauce and meatballs? Sure, it’s a classic and we love the classics, but after the 2,393,984th time, we’re ready for something different. And boy is this different in all of the right ways!

We love dishes that are easily customizable, and cheesy chicken spaghetti is no exception. Prefer shredded chicken? Go for it! Want a little kick of spice? Replace the diced green chilis with diced jalapeños. You really can make this recipe your own by changing it to suit your own personal preferences. 

Can I make cheesy chicken spaghetti vegetarian? 

You can easily make this dish vegetarian by leaving out the chicken. If you want to make sure it is filling enough as the main meal, add an 8oz container of sliced and sautéd crimini or white button mushrooms. 

Cheese Options:

Instead of cheddar cheese, mix things up with Monterey jack, mozzarella, pepper jack, or a Mexican cheese blend.  

A forkful of cheesy chicken spaghetti hovering over its plate

Storage and reheating instructions: 

Store any leftovers in the fridge in an airtight container for up to 4 days. Reheat on the stovetop in a large skillet, adding a few tablespoons of water as needed to thin out the sauce. 

If you like this recipe, you may be interested in these other delicious pasta recipes: